Search results for "Long term response"
showing 3 items of 3 documents
New tools for detecting latent tuberculosis infection: evaluation of RD1-specific long-term response
2009
Abstract Background Interferon-gamma (IFN-γ) release assays (IGRAs) were designed to detect latent tuberculosis infection (LTBI). However, discrepancies were found between the tuberculin skin test (TST) and IGRAs results that cannot be attributed to prior Bacille Calmètte Guerin vaccinations. The aim of this study was to evaluate tools for improving LTBI diagnosis by analyzing the IFN-γ response to RD1 proteins in prolonged (long-term response) whole blood tests in those subjects resulting negative to assays such as QuantiFERON-TB Gold In tube (QFT-IT). Methods The study population included 106 healthy TST+ individuals with suspected LTBI (recent contact of smear-positive TB and homeless) c…
On the long-term response of elastic-perfectly plastic solids to dynamic cyclic loads
1992
It is shown that the long-term response of an elastic-perfectly plastic solid subjected to dynamic actions cyclically varying in time is characterized by stresses, plastic strain rates and velocities that are all periodic with the same period of the external actions, and are in perfect analogy with the quasi-static case; on the other hand, plastic strains and displacements are in general nonperiodic (except in case of alternating plasticity) and may increase indefinitely (except when elastic or plastic shakedown occurs). Besides, the work performed by the external actions in the steady cycle equals the work performed by the elastic stresses (i.e. pertaining to the elastic response of the bo…
Long-Term Response to Cholinesterase Inhibitor Treatment Is Related to Functional MRI Response in Alzheimer's Disease.
2015
<b><i>Background:</i></b> Treatment of Alzheimer's disease (AD) with cholinesterase inhibitors (ChEI) enhances cholinergic activity and alleviates clinical symptoms. However, there is variation in the clinical response as well as system level changes revealed by functional MRI (fMRI) studies. <b><i>Methods:</i></b> We investigated 18 newly diagnosed mild AD patients with fMRI using a face recognition task after a single oral dose of rivastigmine, a single dose of placebo and 1-month treatment with rivastigmine. The clinical follow-up took place at 6 and 12 months. <b><i>Results:</i></b> MMSE score difference between bas…